selected Publications

Arrojo E Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T., Bushong, E., Phan, S., Orphan, V., Lechene, C., Ellisman, M.H., Hetzer, M.W. Age Mosaicism across Multiple Scales in Adult Tissues. (2019) Cell Metabolism. 30(2):343-351. DOI: 10.1016/j.cmet.2019.05.010

McCloskey, A., Ibarra, A., Hetzer, M.W. Tpr regulates the total number of nuclear pore complexes per cell nucleus. (2018) Genes & Development. 32:1321-1331. DOI: 10.1101/gad.315523.118

Franks, T.M., McCloskey, A., Shokirev, M., Benner, C., Rathore, A., Hetzer, M.W. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. (2017) Genes & Development. 31(22):2222-2234. DOI: 10.1101/gad.306753.117

Buchwalter, A., Hetzer, M.W. Nucleolar expansion and elevated protein translation in premature aging. (2017) Nature Communications. 8(1):328. DOI: 10.1038/s41467-017-00322-z

Ibarra, A., Benner, C., Tyagi, S., Cool, J., Hetzer, M.W. Nucleoporin-mediated regulation of cell identity genes. (2016) Genes & Development. 30(20):2253-2258. DOI: 10.1101/gad.287417.116

Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes & Development. 30(10):1155-71. DOI: 10.1101/gad.280941.116

Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R., Hetzer, M.W. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. (2013) Cell. 154(5):971-982. DOI: 10.1016/j.cell.2013.07.037

Hatch, E.M., Fischer, A.H., Deerinck, T.J., Hetzer, M.W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. (2013) Cell. 154(1):47-60. DOI: 10.1016/j.cell.2013.06.007

Doucet, C.M., Talamas, J.A., Hetzer, M.W. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. (2010) Cell. 141(6):1030-41. DOI: 10.1016/j.cell.2010.04.036

Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., Hetzer, M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. (2010) Cell. 140(3):372-83. DOI: 10.1016/j.cell.2009.12.054

D’Angelo, M.A., Raices, M., Panowski, S.H., Hetzer, M.W. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. (2009) Cell. 136(2):284-95. DOI: 10.1016/j.cell.2008.11.037

all Publications

Kaneshiro, J.M., Capitanio, J.S., Hetzer, M.W. Lamin B1 overexpression alters chromatin organization and gene expression. (2023) Nucleus. 14(1):2202548. DOI: 10.1080/19491034.2023.2202548

Cho, U.H., Hetzer, M.W. Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress. (2023) Elife. 12. DOI: 10.7554/eLife.89066

Sharma, R., Hetzer, M.W. Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope. (2023) Life Sci Alliance. 6(8). DOI: 10.26508/lsa.202302031

Shrestha, S., Erikson, G., Lyon, J., Spigelman, A.F., Bautista, A., Manning Fox, J.E., Dos Santos, C., Shokhirev, M., Cartailler, J.P., Hetzer, M.W., MacDonald, P.E., Arrojo E Drigo, R. Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress. (2022) Science Advances. 8(40):eabo3932. DOI: 10.1126/sciadv.abo3932

Hetzer, M.W., Bersini, S. Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging. (2022) Cold Spring Harb Perspect Med. DOI: 10.1101/cshperspect.a041180

Liu, J., Hetzer, M.W. Nuclear pore complex maintenance and implications for age-related diseases. (2021) Trends in Cell Biology. DOI: 10.1016/j.tcb.2021.10.001

Krishna, S., Arrojo E Drigo, R., Capitanio, J.S., Ramachandra, R., Ellisman, M., Hetzer, M.W. Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain. (2021) Developmental Cell. DOI: 10.1016/j.devcel.2021.10.008

Shadel, G.S., Adams, P.D., Berggren, W.T., Diedrich, J.K., Diffenderfer, K.E., Gage, F.H., Hah, N., Hansen, M., Hetzer, M.W., Molina, A.J.A., Manor, U., Marek, K., O’Keefe, D.D., Pinto, A.F.M., Sacco, A., Sharpee, T.O., Shokriev, M.N., Zambetti, S. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. (2021) Geroscience. DOI: 10.1007/s11357-021-00426-x

Bersini, S., Schulte, R., Huang, L., Tsai, H., Hetzer, M.W. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. (2020) Elife. 9. DOI: 10.7554/eLife.54383

Kang, H., Shokhirev, M.N., Xu, Z., Chandran, S., Dixon, J.R., Hetzer, M.W. Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation. (2020) Genes & Development. DOI: 10.1101/gad.335794.119

Cho, U.H., Hetzer, M.W. Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging. (2020) Neuron. 106(6):899-911. DOI: 10.1016/j.neuron.2020.05.031

Bersini, S., Arrojo E Drigo, R., Huang, L., Shokhirev, M.N., Hetzer, M.W. Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease. (2020) Advanced Biosystems. 4(5):e2000044. DOI: 10.1002/adbi.202000044

Bersini, S., Lytle, N.K., Schulte, R., Huang, L., Wahl, G.M., Hetzer, M.W. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. (2020) Life Science Alliance. 3(1). DOI: 10.26508/lsa.201900623

Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., Hetzer, M. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. (2019) Elife. 8. DOI: 10.7554/eLife.49796

Arrojo E Drigo, R., Lev-Ram, V., Tyagi, S., Ramachandra, R., Deerinck, T., Bushong, E., Phan, S., Orphan, V., Lechene, C., Ellisman, M.H., Hetzer, M.W. Age Mosaicism across Multiple Scales in Adult Tissues. (2019) Cell Metabolism. 30(2):343-351. DOI: 10.1016/j.cmet.2019.05.010

Toyama, B.H., Arrojo E Drigo, R., Lev-Ram, V., Ramachandra, R., Deerinck, T.J., Lechene, C., Ellisman, M.H., Hetzer, M.W. Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells. (2018) Journal of Cell Biology. DOI: 10.1083/jcb.201809123

Fleischer, J.G., Schulte, R., Tsai, H.H., Tyagi, S., Ibarra, A., Shokhirev, M.N., Huang, L., Hetzer, M.W., Navlakha, S. Predicting age from the transcriptome of human dermal fibroblasts. (2018) Genome Biology. 19(1):221. DOI: 10.1186/s13059-018-1599-6

Buchwalter, A., Kaneshiro, J.M., Hetzer, M.W. Coaching from the sidelines: the nuclear periphery in genome regulation. (2018) Nature Reviews Genetics. DOI: 10.1038/s41576-018-0063-5

McCloskey, A., Ibarra, A., Hetzer, M.W. Tpr regulates the total number of nuclear pore complexes per cell nucleus. (2018) Genes & Development. 32:1321-1331. DOI: 10.1101/gad.315523.118

Franks, T.M., McCloskey, A., Shokirev, M., Benner, C., Rathore, A., Hetzer, M.W. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. (2017) Genes & Development. 31(22):2222-2234. DOI: 10.1101/gad.306753.117

Toda, T., Hsu, J.Y., Linker, S.B., Hu, L., Schafer, S.T., Mertens, J., Jacinto, F.V., Hetzer, M.W., Gage, F.H. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. (2017) Cell Stem Cell. 21:618–634. DOI: 10.1016/j.stem.2017.08.012

Buchwalter, A., Hetzer, M.W. Nucleolar expansion and elevated protein translation in premature aging. (2017) Nature Communications. 8(1):328. DOI: 10.1038/s41467-017-00322-z

van de Ven, R.A., de Groot, J.S., Park, D., van Domselaar, R., de Jong, D., Szuhai, K., van der Wall, E., Rueda, O.M., Ali, H.R., Caldas, C., van Diest, P.J., Hetzer, M.W., Sahai, E., Derksen, P.W. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. (2016) Nature Communications. 7:13874. DOI: 10.1038/ncomms13874

Ibarra, A., Benner, C., Tyagi, S., Cool, J., Hetzer, M.W. Nucleoporin-mediated regulation of cell identity genes. (2016) Genes & Development. 30(20):2253-2258. DOI: 10.1101/gad.287417.116

Hatch, E.M., Hetzer, M.W. Nuclear envelope rupture is induced by actin-based nucleus confinement. (2016) Journal of Cell Biology. 215(1):27-36. DOI: 10.1083/jcb.201603053

Franks, T.M., Benner, C., Narvaiza, I., Marchetto, M.C., Young, J.M., Malik, H.S., Gage, F.H., Hetzer, M.W. Evolution of a transcriptional regulator from a transmembrane nucleoporin. (2016) Genes & Development. 30(10):1155-71. DOI: 10.1101/gad.280941.116

Mertens, J., Paquola, A.C., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J.R., Gonçalves, J.T., Toda, T., Kim, Y., Winkler, J., Yao, J., Hetzer, M.W., Gage, F.H. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. (2015) Cell Stem Cell. 17(6):705-18. DOI: 10.1016/j.stem.2015.09.001

Ori, A., Toyama, B.H., Harris, M.S., Bock, T., Iskar, M., Bork, P., Ingolia, N.T., Hetzer, M.W., Beck, M. Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. (2015) Cell Systems. 1(3):224-37. DOI: 10.1016/j.cels.2015.08.012

Hatch, E.M., Hetzer, M.W. Linking Micronuclei to Chromosome Fragmentation. (2015) Cell. 161(7):1502-4. DOI: 10.1016/j.cell.2015.06.005

Jacinto, F.V., Benner, C., Hetzer, M.W. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. (2015) Genes & Development. 29(12):1224-38. DOI: 10.1101/gad.260919.115

Hatch, E.M., Hetzer, M.W. Chromothripsis. (2015) Current Biology. 25(10):R397-9. DOI: 10.1016/j.cub.2015.02.033

Gomez-Cavazos, J.S., Hetzer, M.W. The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis. (2015) Journal of Cell Biology. 208(6):671-81. DOI: 10.1083/jcb.201410047

Ibarra, A., Hetzer, M.W. Nuclear pore proteins and the control of genome functions. (2015) Genes & Development. 29(4):337-49. DOI: 10.1101/gad.256495.114

Buchwalter, A.L., Liang, Y., Hetzer, M.W. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. (2014) Molecular Biology of the Cell. 25(16):2472-84. DOI: 10.1091/mbc.E14-04-0865

Hatch, E., Hetzer, M. Breaching the nuclear envelope in development and disease. (2014) Journal of Cell Biology. 205(2):133-41. DOI: 10.1083/jcb.201402003

Buchwalter, A., Hetzer, M.W. Nuclear pores set the speed limit for mitosis. (2014) Cell. 156(5):868-9. DOI: 10.1016/j.cell.2014.02.004

Toyama, B.H., Savas, J.N., Park, S.K., Harris, M.S., Ingolia, N.T., Yates, J.R., Hetzer, M.W. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. (2013) Cell. 154(5):971-982. DOI: 10.1016/j.cell.2013.07.037

Hatch, E.M., Fischer, A.H., Deerinck, T.J., Hetzer, M.W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. (2013) Cell. 154(1):47-60. DOI: 10.1016/j.cell.2013.06.007

Regner, B.M., Vučinić, D., Domnisoru, C., Bartol, T.M., Hetzer, M.W., Tartakovsky, D.M., Sejnowski, T.J. Anomalous diffusion of single particles in cytoplasm. (2013) Biophysical Journal. 104(8):1652-60. DOI: 10.1016/j.bpj.2013.01.049

Franks, T.M., Hetzer, M.W. The role of Nup98 in transcription regulation in healthy and diseased cells. (2013) Trends in Cell Biology. 23(3):112-7. DOI: 10.1016/j.tcb.2012.10.013

Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H., Hetzer, M.W. Dynamic association of NUP98 with the human genome. (2013) PLOS Genetics. 9(2):e1003308. DOI: 10.1371/journal.pgen.1003308

Toyama, B.H., Hetzer, M.W. Protein homeostasis: live long, won’t prosper. (2013) Nature Reviews Molecular Cell Biology. 14(1):55-61. DOI: 10.1038/nrm3496

Gomez-Cavazos, J.S., Hetzer, M.W. Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. (2012) Current Opinion in Cell Biology. 24(6):775-83. DOI: 10.1016/j.ceb.2012.08.008

Hatch, E.M., Hetzer, M.W. RNP export by nuclear envelope budding. (2012) Cell. 149(4):733-5. DOI: 10.1016/j.cell.2012.04.018

D’Angelo, M.A., Gomez-Cavazos, J.S., Mei, A., Lackner, D.H., Hetzer, M.W. A change in nuclear pore complex composition regulates cell differentiation. (2012) Developmental Cell. 22(2):446-58. DOI: 10.1016/j.devcel.2011.11.021

Savas, J.N., Toyama, B.H., Xu, T., Yates, J.R., Hetzer, M.W. Extremely long-lived nuclear pore proteins in the rat brain. (2012) Science. 335(6071):942. DOI: 10.1126/science.1217421

Vargas, J.D., Hatch, E.M., Anderson, D.J., Hetzer, M.W. Transient nuclear envelope rupturing during interphase in human cancer cells. (2012) Nucleus. 3(1):88-100. DOI: 10.4161/nucl.18954

Talamas, J.A., Hetzer, M.W. POM121 and Sun1 play a role in early steps of interphase NPC assembly. (2011) Journal of Cell Biology. 194(1):27-37. DOI: 10.1083/jcb.201012154

Hetzer, M., Cavalli, G. Eukaryotic cells. (2011) Current Opinion in Cell Biology. 23(3):255-7. DOI: 10.1016/j.ceb.2011.04.013

Liang, Y., Hetzer, M.W. Functional interactions between nucleoporins and chromatin. (2011) Current Opinion in Cell Biology. 23(1):65-70. DOI: 10.1016/j.ceb.2010.09.008

Doucet, C.M., Hetzer, M.W. Nuclear pore biogenesis into an intact nuclear envelope. (2010) Chromosoma. 119(5):469-77. DOI: 10.1007/s00412-010-0289-2

Hetzer, M. Martin Hetzer: taking the nuclear membrane beyond the barrier. (2010) Journal of Cell Biology. 190(4):484-5. DOI: 10.1083/jcb.1904pi

Doucet, C.M., Talamas, J.A., Hetzer, M.W. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. (2010) Cell. 141(6):1030-41. DOI: 10.1016/j.cell.2010.04.036

Capelson, M., Doucet, C., Hetzer, M.W. Nuclear pore complexes: guardians of the nuclear genome. (2010) Cold Spring Harbor Symposia on Quantitative Biology. 75:585-97. DOI: 10.1101/sqb.2010.75.059

Hetzer, M.W. The role of the nuclear pore complex in aging of post-mitotic cells. (2010) Aging. 2(2):74-5. DOI: 10.18632/aging.100125

Hetzer, M.W. The nuclear envelope. (2010) Cold Spring Harbor Perspectives in Biology. 2(3):a000539. DOI: 10.1101/cshperspect.a000539

Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., Hetzer, M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. (2010) Cell. 140(3):372-83. DOI: 10.1016/j.cell.2009.12.054

Hetzer, M.W., Wente, S.R. Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes. (2009) Developmental Cell. 17(5):606-16. DOI: 10.1016/j.devcel.2009.10.007

Anderson, D.J., Vargas, J.D., Hsiao, J.P., Hetzer, M.W. Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo. (2009) Journal of Cell Biology. 186(2):183-91. DOI: 10.1083/jcb.200901106

Capelson, M., Hetzer, M.W. The role of nuclear pores in gene regulation, development and disease. (2009) EMBO Reports. 10(7):697-705. DOI: 10.1038/embor.2009.147

Dawson, T.R., Lazarus, M.D., Hetzer, M.W., Wente, S.R. ER membrane-bending proteins are necessary for de novo nuclear pore formation. (2009) Journal of Cell Biology. 184(5):659-75. DOI: 10.1083/jcb.200806174

D’Angelo, M.A., Raices, M., Panowski, S.H., Hetzer, M.W. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. (2009) Cell. 136(2):284-95. DOI: 10.1016/j.cell.2008.11.037

Kutay, U., Hetzer, M.W. Reorganization of the nuclear envelope during open mitosis. (2008) Current Opinion in Cell Biology. 20(6):669-77. DOI: 10.1016/j.ceb.2008.09.010

D’Angelo, M.A., Hetzer, M.W. Structure, dynamics and function of nuclear pore complexes. (2008) Trends in Cell Biology. 18(10):456-66. DOI: 10.1016/j.tcb.2008.07.009

Anderson, D.J., Hetzer, M.W. Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation. (2008) Journal of Cell Biology. 182(5):911-24. DOI: 10.1083/jcb.200805140

Anderson, D.J., Hetzer, M.W. The life cycle of the metazoan nuclear envelope. (2008) Current Opinion in Cell Biology. 20(4):386-92. DOI: 10.1016/j.ceb.2008.03.016

Schulte, R., Talamas, J., Doucet, C., Hetzer, M.W. Single bead affinity detection (SINBAD) for the analysis of protein-protein interactions. (2008) PLOS One. 3(4):e2061. DOI: 10.1371/journal.pone.0002061

Anderson, D.J., Hetzer, M.W. Shaping the endoplasmic reticulum into the nuclear envelope. (2008) Journal of Cell Science. 121(Pt 2):137-42. DOI: 10.1242/jcs.005777

Anderson, D.J., Hetzer, M.W. Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum. (2007) Nature Cell Biology. 9(10):1160-6. DOI: 10.1038/ncb1636

Franz, C., Walczak, R., Yavuz, S., Santarella, R., Gentzel, M., Askjaer, P., Galy, V., Hetzer, M., Mattaj, I.W., Antonin, W. MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. (2007) EMBO Reports. 8(2):165-72. DOI: 10.1038/sj.embor.7400889

D’Angelo, M.A., Anderson, D.J., Richard, E., Hetzer, M.W. Nuclear pores form de novo from both sides of the nuclear envelope. (2006) Science. 312(5772):440-3. DOI: 10.1126/science.1124196

D’Angelo, M.A., Hetzer, M.W. The role of the nuclear envelope in cellular organization. (2006) Cellular and Molecular Life Sciences. 63(3):316-32. DOI: 10.1007/s00018-005-5361-3

Hetzer, M.W., Walther, T.C., Mattaj, I.W. Pushing the envelope: structure, function, and dynamics of the nuclear periphery. (2005) Annual Review of Cell and Developmental Biology. 21:347-80. DOI: 10.1146/annurev.cellbio.21.090704.151152

Walther, T.C., Askjaer, P., Gentzel, M., Habermann, A., Griffiths, G., Wilm, M., Mattaj, I.W., Hetzer, M. RanGTP mediates nuclear pore complex assembly. (2003) Nature. 424(6949):689-94. DOI: 10.1038/nature01898

Walther, T.C., Alves, A., Pickersgill, H., Loïodice, I., Hetzer, M., Galy, V., Hülsmann, B.B., Köcher, T., Wilm, M., Allen, T., Mattaj, I.W., Doye, V. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. (2003) Cell. 113(2):195-206. DOI: 10.1016/S0092-8674(03)00235-6

Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P.B., Mattaj, I.W. Ran binds to chromatin by two distinct mechanisms. (2002) Current Biology. 12(13):1151-6.

Hetzer, M., Gruss, O.J., Mattaj, I.W. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. (2002) Nature Cell Biology. 4(7):E177-84. DOI: 10.1038/ncb0702-e177